Levels of CA125, HE4, mezotelina increase over 3 years prior to diagnosis of ovarian cancer

A study conducted by American scientists have suggested that serum level of CA125, the human epididymis protein 4 (HE4), and mesothelin increase over three years prior to diagnosis of ovarian cancer, but significantly increased only during the year prior to diagnosis.

"The duration of the preclinical period, observed in this study gives some hope that the time period before diagnosis, is 3 years or more, can be obtained if the identified correct circulating protein", - said Garnet Anderson (Garnet Anderson) (Fred Hutchinson Cancer Center, Seattle, Washington, USA) and colleagues.

Scientists have used immunological tests to determine the concentration of CA125, HE4, mesothelin, B7-H4, decoy receptor 3, spondin-2 proteins in stored serum samples 34 patients with subsequent diagnosis of ovarian cancer and 70 control patients who participated in himiopreventivnom cancer research lungs

Serum concentrations of CA125, HE4, and mesothelin began to grow somewhat in ovarian cancer patients, approximately three years before diagnosis, but reached high levels only in the final years before diagnosis.

Regression analysis showed that women with CA125 levels 53 U / ml of a 1-year probability of ovarian cancer is approximately 1.4 times higher than that in women with levels 16 U / ml. Further analysis showed that HE4, mesothelin, and spondin-2 are also associated with a significantly increased risk of ovarian cancer, with risk ratios ranging from 1.35 to 1.58.

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